DISSEMINATED TRICHOSPORONOSIS INVOLVING LOBAR NEPHRONIA, MUSCULAR ABSCESSES AND CUTANEOUS PAPULES IN A PATIENT WITH ACUTE LYMPHOBLASTIC LEUKEMIA: A CASE REPORT
DOI:
https://doi.org/10.55374/jseamed.v8.200Keywords:
Trichosporon asahii, Lobar nephronia, muscular abscess, fungemia, voriconazoleAbstract
Trichosporon asahii has emerged as a severe life-threatening, opportunistic, systemic pathogen along with high mortality rates because of the increased use of cytotoxic or immunosuppressive drugs. We report a case of catheter-related T. asahii bloodstream infection complicated with multiple septic skin lesions in the extremities, lobar nephronia, and a muscular abscess in the neutropenic period after receiving chemotherapy. We successfully treated T. asahii infection using voriconazole for ten weeks without complications.
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Asada N, Uryu H, Koseki M, Takeuchi M, Komatsu M, Matsue K. Successful treatment of breakthrough Trichosporon asahii fungemia with voriconazole in a patient with acute myeloid leukemia. Clin Infect Dis 2006; 43: e39-41. https://doi.org/10.1086/505970
Ruan SY, Chien JY, Hsueh PR. Invasive trichosporonosis caused by Trichosporon asahii and other unusual Trichosporon species at a medical center in Taiwan. Clin Infect Dis 2009; 49:11-7. https://doi.org/10.1086/599614
Nualmalang R, Thanomsridetchai N, Teethaisong Y, Sukphopetch P, Tangwattanachuleeporn M. Identification of pathogenic and opportunistic yeasts in pigeon excreta by MALDI-TOF mass spectrometry and their prevalence in Chon Buri Province, Thailand. Int J Environ Res Public Health 2023; 20: 3191. https://doi.org/10.3390/ijerph20043191
Haynes KA, Westerneng TJ, Fell JW, Moens W. Rapid detection and identification of pathogenic fungi by polymerase chain reaction amplification of large subunit ribosomal DNA. J Med Vet Mycol 1995; 33: 319-25. https://doi.org/10.1080/02681219580000641
Colombo AL, Padovan AC, Chaves GM. Current knowledge of Trichosporon spp. and Trichosporonosis. Clin Microbiol Rev 2011; 24: 682-700. https://doi.org/10.1128/CMR.00003-11
Oelz O, Schaffner A, Frick P, Schaer G. Trichosporon capitatum: thrush-like oral infection, local invasion, fungaemia and metastatic abscess formation in a leukemic patient. J Infect 1983; 6: 183-5. https://doi.org/10.1016/S0163-4453(83)92942-0
Arendrup MC, Boekhout T, Akova M, Meis JF, Cornely OA, Lortholary O; European Society of Clinical Microbiology and Infectious Diseases Fungal Infection Study Group; European Confederation of Medical Mycology. ESCMID and ECMM joint clinical guidelines for the diagnosis and management of rare invasive yeast infections. Clin Microbiol Infect 2014; 20 (Suppl 3): 76-98. https://doi.org/10.1111/1469-0691.12360
Menezes EA, Marinho JA, Angelo MR, Cunha Mda C, Cunha FA, Vasconcelos Júnior AA. Isolation and antifungal antifungal susceptibility testing of Trichosporon asahii in Ceará, Brazil. Rev Inst Med Trop Sao Paulo 2012; 54: 1-3. https://doi.org/10.1590/S0036-46652012000100001
Suzuki K, Nakase K, Kyo T, Kohara T, Sugawara Y, Shibazaki T, Oka K, Tsukada T, Katayama N. Fatal Trichosporon fungemia in patients with hematologic malignancies. Eur J Hematol 2010; 84: 441-7. https://doi.org/10.1111/j.1600-0609.2010.01410.x
Nachbaur D, Angelova O, Orth-Höller D, Ditlbacher A, Lackner M, Auberger J, et al. Primary antifungal prophylaxis with micafungin in patients with hematological malignancies: real-life data from a retrospective single-center observational study. Eur J Hematol 2015; 94: 258-64. https://doi.org/10.1111/ejh.12426
Fournier S, Pavageau W, Feuillhade M, Deplus S, Zagdanski AM, Verola O, et al. Use of voriconazole to successfully treat dissemienated Trichosporon asahii infection in a patient with acute myeloid leukemia. Eur J Clin Microbiol Infect Dis 2002; 21: 892-6. https://doi.org/10.1007/s10096-002-0841-y
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