https://jseamed.org/index.php/jseamed/issue/feedJournal of Southeast Asian Medical Research2024-03-07T15:00:54+07:00Professor Mathirut Mungthin, M.D., Ph.DMathirut@hotmail.comOpen Journal Systems<p> </p> <p> </p>https://jseamed.org/index.php/jseamed/article/view/186ASSOCIATION OF THE TYPE OF INTRACEREBRAL HEMORRHAGE WITH SERIOUS COMPLICATIONS AND PREDICTIVE FACTORS FOR HEMORRHAGIC TRANSFORMATION AFTER THROMBOLYTIC TREATMENT IN PATIENTS WITH ACUTE ISCHEMIC STROKE2024-02-19T07:43:38+07:00Sarawut KrongsutWipasiri Naraphong Surachet Srikaew Niyada Anusasnee <p><strong>Background:</strong> Accurate classification of postthrombolytic intracerebral hemorrhage (ICH) subtypes is vital for predicting stroke outcomes and managing ICH. Currently, the recommended classification criteria are the European Cooperative Acute Stroke Study III criteria, including two primary categories: hemorrhagic infarction (HI) and parenchymal hematoma (PH).</p> <p><strong>Objectives:</strong> The primary objective of this study was to assess the contribution of various ICH subtypes to serious complications, with the secondary aim to identify associated predictors.<br />Methods: The study examined medical records of patients with acute ischemic stroke receiving thrombolysis at Saraburi Hospital from 2014 to 2022. The logit model with the margins command assessed the association of ICH subtypes with serious complications, and multinomial logistic regression identified potential predictors for HI and PH.</p> <p><strong>Results:</strong> Among 345 patients, HI-1, HI-2, PH-1 and PH-2 had prevalence rates of 3.2, 7.8, 4.9 and 7.5%, respectively, while 76.5% did not have ICH. PH-2 demonstrated the strongest correlation with inhospital mortality (adjusted risk ratio [RR] 2.83, 95% CI 1.56-5.13), invasive mechanical ventilator requirement (adjusted RR 3.93, 95% CI 2.09-7.39) and hematoma evacuation (adjusted RR 4.58, 95% CI 1.17-17.95) compared with patients of non-ICH. HI demonstrated a significant prolongation of hospitalization. (adjusted RR 3.30, 95% CI 1.53-7.12). Multinomial logistic regression analysis revealed that prior use of antiplatelet drugs, antihypertensive treatment before rt-PA, white blood cell count ≥11,750 cells/mm3 and baseline Alberta stroke program early CT scores ≤7 were independent predictors for PH. The adjusted odds ratios were 3.06 (95% CI, 1.23-7.57), 6.95 (95% CI, 2.62-18.45), 6.01 (95% CI, 2.17-16.65) and 5.01 (95% CI, 2.00-12.60), respectively.</p> <p><strong>Conclusion:</strong> The PH-2 subtype was associated with the highest mortality, while our study demonstrated that the HI subtype, previously considered relatively benign with successful early recanalization, showed a significant prolongation of hospitalization compared with that of patients of non-ICH. High-risk patients of ICH require intensive monitoring to reduce complications.</p>2024-02-19T00:00:00+07:00Copyright (c) 2024 Journal of Southeast Asian Medical Researchhttps://jseamed.org/index.php/jseamed/article/view/188STUDY OF GLYCEMIC INDEX OF DIABETES-SPECIFIC MODIFIED FORMULA AMONG HEALTHY ADULTS2024-03-01T17:34:43+07:00Apussanee Boonyavarakul<p><strong>Background:</strong> People with type 2 diabetes incorporate diabetes-specific nutritional formulas (DSNFs) in their nutrition therapy to enhance glycemic control and manage body weight. Among these formulas, the GEN-DM modified formula (GEN-DM MF) has been widely used for several years. However, the glycemic index (GI) of GEN-DM MF has not yet been determined.</p> <p><strong>Objective:</strong> This study aimed to assess the GI of GEN-DM MF.</p> <p><strong>Methods:</strong> Ten healthy adults with normal oral glucose tolerance were included. The plasma glucose was measured at 0 (baseline), 30, 60, 90 and 120 minutes after consuming 50 grams of glucose solution. On the subsequent two days, plasma glucose measurement was repeated using 84.46 g of GEN-DM MF containing 50 g of carbohydrates. The GI was calculated by dividing the incremental area under the glucose response curve (iAUC) of GEN-DM MF by the area under the glucose response curve of the glucose solution, then multiplying the result by 100. The glycemic load (GL) was calculated by multiplying the GI by the carbohydrate amount in one serving of GEN-DM MF (40 g) /100.</p> <p><strong>Results:</strong> Six healthy men and four women with an average age of 35.80 ± 6.89 years, ranging from 28 to 44, were included in the study. The plasma glucose levels at 30 and 60 minutes following the GEN-DM MF were significantly lower than the corresponding glucose levels with p= 0.002 and 0.013, respectively. The GI and GL of GEN-DM MF were 37.75 and 9, respectively, which was classified as low GI and low GL.</p> <p><strong>Conclusion:</strong> GEN-DM MF is classified as a low GI and low GL food, which could significantly lower plasma glucose levels among healthy individuals.</p>2024-03-01T00:00:00+07:00Copyright (c) 2024 Journal of Southeast Asian Medical Researchhttps://jseamed.org/index.php/jseamed/article/view/195PRIMARY SPONTANEOUS PNEUMOTHORAX IN A PATIENT OF MILD COVID-19 WITHOUT ANY RISK FACTORS: A CASE REPORT2024-03-07T15:00:54+07:00Sudipto ChakrabortyRajeswar SamantaSandip ChandraSusobhan MondalSyamasis Bandhyopadhyay<p>A 36-year-old man with a recent history of lower respiratory tract infection of mild COVID-19 was treated at home without any comorbidities or addiction. He was sent to the emergency department after day 14 of COVID-19 infection. He complained of sudden onset right-sided chest pain with gradually increasing shortness of breath on exertion for three days. He received a diagnosis of primary spontaneous pneumothorax clinically and radiologically. An intercostal chest drain was inserted, which was removed after clinical recovery and radiologic re-expansion. He was discharged and followed up at the outpatient department; he was in good health and resumed his usual activities.</p>2024-03-07T00:00:00+07:00Copyright (c) 2024 Journal of Southeast Asian Medical Research