PREVALENCE OF ABNORMAL GLUCOSE METABOLISM AMONG THAI OVERWEIGHT AND OBESE CHILDERN AND ADOLESCENTS

Authors

  • Pacharin Mungklarat Division of Endocrinology, Department of Pediatrics, Phramongkutklao Hospial and Phramongkutklao College of Medicine
  • Anothai Juttuporn Division of Community, Occupational and Family Medicine, Faculty of Medicine, Burapha University
  • Wiphakorn Suphaphimon Division of Endocrinology, Department of Pediatrics, Phramongkutklao Hospial and Phramongkutklao College of Medicine
  • Warissara Sanor Division of Endocrinology, Department of Pediatrics, Phramongkutklao Hospial and Phramongkutklao College of Medicine
  • Chula Kooanantkul Kids Center, Vejthani Hospital
  • Nawaporn Numbenjapon Division of Endocrinology, Department of Pediatrics, Phramongkutklao Hospial and Phramongkutklao College of Medicine
  • Voraluck Phatarakijinirund Division of Endocrinology, Department of Pediatrics, Phramongkutklao Hospial and Phramongkutklao College of Medicine

DOI:

https://doi.org/10.55374/jseamed.v3i2.41

Keywords:

Impaired glucose tolerance, Imparied fasting glucose, Type 2 diabetes, Insulin resistance

Abstract

Background: The prevalence of childhood obesity is in creasingly worldwide. Abnormal glucose metabolism (ASM) including impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and type 2 diabetes (T2DM) is a common endocrine complication among overweight and obese children and adolescents. Few studies of AGM are available in Thailand.
Objectives: The study aimed to establish the prevalence of AGM and identify associated complications among overweight and obese children and adolescents.
Methods: Data of overweight and obese children and adolescents, aged 6 to 18 years, undergoing oral glucose tolerance test (OGTT) at phramongkutklao Hospital were reviewed retrospectively. Fasting blood sugar, Hemoglobin Ale (HbA1c). fasting insulin, triglyceride, high-density lipoprotein, low-density lipoprotein, aspartate transaminase and alanine aminotransferase were derived from fasting measurement. Homeostatic model assessment was calculated to represent the insulin resistance.
Result: A total of 204 children and adolescents (122 males) were included. Mean age was 12.1 ± 2.6 years and percent weight for height was 168.8 ± 25.4% The overall prevalence of AGM was 20.6%, 1 % had T2DM, 0.5% had IFG, 36% had IGT and 1.5% had combined IFG/IGT. Among the AGM, IGT was the most frequent subtype representing 92.8% (39/42 cases) but only 2 cases of T2DM were diagnosed in our study. The AGM group had significantly higher FPG (p=0.034), HbA1c (p=0.006) and cholesterol levels (p=0.043) than those of the nonabnormal glucose metabolism (NGM) group
Conclusion: Prevalences of AGM among overweight and obese children and adolescents were high. IGT was the most frequent group.

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References

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Published

2019-12-01

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1.
Mungklarat P, Juttuporn A, Suphaphimon W, Sanor W, Kooanantkul C, Numbenjapon N, et al. PREVALENCE OF ABNORMAL GLUCOSE METABOLISM AMONG THAI OVERWEIGHT AND OBESE CHILDERN AND ADOLESCENTS. J Southeast Asian Med Res [Internet]. 2019 Dec. 1 [cited 2024 Apr. 17];3(2):59-66. Available from: https://jseamed.org/index.php/jseamed/article/view/41

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